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Lastly, clonidine boosts neuraxial opioids and, together with fentanyl, interacts in an additive way, which may reduce the dose of every component by 60% for postoperative analgesia.Jun 10, 2024 · If clonidine therapy should be to get replaced by a β-blocker, hold off administration on the β-blocker for various times right after clonidine thera